A new Gulf War and Health Series by the Institute of Medicine reports that individualized treatments for veterans with Gulf War Syndrome are needed. Gulf War Syndrome, characterized as a chronic multisystem illness (CMI), and defined as having symptoms in at least two of six categories–fatigue, mood and cognition, musculoskeletal, gastrointestinal, respiratory, and neurologic—which last for at least six months. Gulf War Syndrome affects at least one-third of veterans of the 1991 Persian Gulf War. The recommended treatment approaches include antidepressant drugs and cognitive behavioral therapy, and the report calls for further research in biofeedback, aerobic exercise, and acupuncture treatments. This new report will provide guidance for healthcare providers who treat the 235,398 Gulf War era veterans who reside in North Carolina.